Immunoregulatory role of acid sphingomyelinase in allergic asthma
نویسندگان
چکیده
منابع مشابه
Immunoregulatory role of secretory leukocyte protease inhibitor in allergic asthma
Background Asthma is a complex and multi-factorial inflammatory disease [1]. It is one of the most common chronic diseases among children and adolescents [2]. Secretory leukocyte protease inhibitor (SLPI) has shown higher levels in asthmatic patients and its function as an anti-inflammatory protein has been documented in respiratory diseases [3,4]. However, its role in the immunomodulation of t...
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Allergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation. HLA-G molecules, both in membrane-bound and in soluble forms, play a central role in modulation of immune responses. Elevated levels of soluble HLA-G (sHLA-G) molecules are detected in serum of patients with allergic rhinitis to se...
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ژورنال
عنوان ژورنال: Immunology
سال: 2019
ISSN: 0019-2805,1365-2567
DOI: 10.1111/imm.13035